Niels van den Berg

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

This study shows that having more long-lived ancestors is linked to longer healthspan and better mid-life metabolomic profiles in families.

The paper examines whether the survival advantage of offspring from long-lived parents is genetic or environmental, finding a genetic component that persists beyond age 5.

The paper identifies heritable longevity carriers using a family score and shows that longevity is transmitted across generations when at least 20% of relatives are long-lived.

The paper shows that longevity as top 10% survivors is a quantitative genetic trait, with a 31% survival advantage in families with long-lived relatives.