Thies Gehrmann

From Diversity to Dominance: How Salt and CO2 Shape LAB-dominated Ecosystems in Vegetable Fermentations

This study investigates how salt and CO2 levels influence microbial community dynamics in vegetable fermentations, showing that lower salt delays LAB dominance while CO2 mitigates Enterobacterales growth.

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

Vitamin B2 Production by Vaginal Lactobacilli Promotes Symbiosis

This study identifies riboflavin production by vaginal lactobacilli and shows its role in modulating host immune responses and redox balance.

The female intimate microbiome space

The paper examines microbial dispersal across female intimate body sites and finds lactobacilli are unexpectedly abundant on breast skin.

T cell-microbiome associations captured through T cell receptor convergence analysis

The paper introduces AIRRWAS, a framework to identify T cell receptor convergence with bacterial genera, revealing reproducible associations across cohorts and functional T cell responses.

Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients

This study shows that Lacticaseibacillus rhamnosus GG chewables colonize the nose and reduce allergy symptoms and cytokines in allergic rhinitis patients.

DNA methylation and gene expression trajectories of human postprandial metabolism

The paper identifies DNA methylation and gene expression changes in human blood after a meal, linking them to cardiometabolic health and obesity-related genes.

Bridging immunotypes and enterotypes using a systems immunology approach

The paper links immunotypes and enterotypes through a systems immunology approach, showing they are orthogonal and connected via the blood transcriptome, with associations between specific bacteria and immune health.

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

This study examines how a lifestyle intervention affects the blood transcriptomic and metabolomic responses to a nutrient challenge in elderly individuals.

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

The paper identifies two rare variants in the MAPK/ERK pathway from long-lived families and shows they affect signaling and metabolism differently in mouse embryonic stem cells.

Variants in RNA-Seq data show a continued mutation rate during strain preservation of Schizophyllum commune

The paper analyzes RNA-seq data from Schizophyllum commune to show that spontaneous mutations accumulate during strain preservation, with a mutation rate of 1.923×10^-8 per haploid genome per base per generation.