BioinformaticsbioRxivPreprint
Topology-aware reconstruction of cellular state landscapes from microscopy using self-supervised learning
Elisa Messori, Doaa M. Taha, Lisa Mathilde Fournier…·Raphaëlle Luisier
The paper introduces SI-SimCLR, a self-supervised learning framework for reconstructing cellular phenotypic landscapes from microscopy data without segmentation or annotation, revealing substate organization and connections in astrocytes.