MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytes
Bruno Ghirotto, Danyllo Oliveira, Marcella Cipelli, Paulo José Basso, Jean de Lima, Cristiane Naffah de Souza Breda, Henrique Caracho Ribeiro, Camille C. C. Silva, Andrea Laurato Sertie, Antônio Edson Rocha Oliveira, Meire Ioshie Hiyane, Elia Tamaso Espin Garcia Caldini, Alessandra Sussulini, Helder Imoto Nakaya, Alicia Juliana Kowaltowski, , Niels Olsen Saraiva Câmara
This study characterizes metabolic alterations in iPSC-derived astrocytes from MS patients, identifying mitochondrial dysfunction and distinct metabolic profiles linked to disease mechanisms.
Annals of Neurology · Feb 28, 2022Peer-reviewedNeuroscience