Author

Bruno Ghirotto

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0001-6835-3329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Beate WinneriD· 2 shared Claudia GüntheriD· 2 shared Markus NeurathiD· 2 shared Alejandra Pizano· 1 shared Alessandra SussuliniiD· 1 shared Alicia Juliana KowaltowskiiD· 1 shared Andrea Laurato SertieiD· 1 shared Anne HartebrodtiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Beate WinnerORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 28, 2026

A neuroimmune IL-13 axis is associated with human enteric nervous system development

Luis Eduardo Duarte Gonçalves, Bruno Ghirotto, Alejandra Pizano…·Sonja Diez

This study identifies a neuroimmune IL-13 axis involved in human enteric nervous system development through transcriptomic and functional analyses of neonatal ileum tissue.

DOI 10.64898/2026.05.27.728110

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedApr 1, 2026

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients

Bruno Ghirotto, Luís Eduardo Gonçalves, Vivien Ruder…·Beate Winner

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceAnnals of NeurologyPeer-reviewedFeb 28, 2022

MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytes

Bruno Ghirotto, Danyllo Oliveira, Marcella Cipelli…·Niels Olsen Saraiva Câmara

This study characterizes metabolic alterations in iPSC-derived astrocytes from MS patients, identifying mitochondrial dysfunction and distinct metabolic profiles linked to disease mechanisms.

21 citations

humanbulk RNA-seq

𝕏 PostBluesky