Yuezhi Lin

This study identifies how EIAV vaccine Env regulates NLRP3 inflammasome activation by reducing NLRP3-NEK7 complex formation while preserving P2X7-mediated ion flux.

The paper identifies a novel fully-spliced transcript from EIAV that encodes a protein named Mat, which depends on Rev and the CRM1 pathway for nuclear export, suggesting a new Rev-responsive element.