Developmental BiologyCell DiscoveryPeer-reviewed
Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos
Jingyu Li, Jiaming Zhang, Weibo Hou…·Qingran Kong
This study identifies metabolic features in mouse pre-implantation embryos and shows that NAD+ synthesis is essential for development and regulates minor ZGA through H3K27ac erasure.
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