Author

Albert Escobedo

Wellcome Sanger InstituteORCID 0000-0001-7295-5111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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André J. FaureiD· 1 shared Ben LehneriD· 1 shared Gesa VoigtiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

André J. FaureORCID

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1 paper

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BiophysicsSciencePeer-reviewedJul 24, 2025

Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution

Albert Escobedo, Gesa Voigt, André J. Faure, Ben Lehner

The paper evaluates the stability and function of randomized hydrophobic protein cores across evolutionary distances, finding that allostery disrupts function despite stable cores.

44 citationstop 1%

protein structureexperimental assay

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