Cancer BiologyCancersPeer-reviewed
Unveiling the Mechanisms to Bypass KRAS Inhibition: In Vitro Insights into the Influence of Fibroblast-Secretome
Susana Mendonça, Patrícia Dias Carvalho, André Serra‐Roma…·Sérgia Velho
This study investigates how fibroblast-secreted factors promote KRAS-independent stemness in KRAS-mutant CRC cells, revealing a mechanism by which the tumor microenvironment contributes to resistance to KRAS inhibition.
2 citations