Synthetic BiologybioRxivPreprint
Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry
Zi‐Qi Li, Ruijie K. Zhang, Pei‐Pei Xie…·Frances H. Arnold
This study combines design and evolution to create new-to-nature enzymes capable of performing regio- and enantioselective C-H amination reactions for synthesizing chiral piperidines.
DOI 10.64898/2026.10.01.754751