Author

Jacob Kelly

Google DeepMind (United Kingdom)ORCID 0000-0002-2175-5686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:deep learning· 1

Frequent Co-Authors

Amy E. DansoniD· 2 shared Frances H. ArnoldiD· 2 shared Josh AbramsoniD· 2 shared Jue WangiD· 2 shared Peng LiuiD· 2 shared Pushmeet KohliiD· 2 shared Ruijie K. ZhangiD· 2 shared Sukhdeep SinghiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Amy E. DansonORCID

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2 papers

Recent·Most cited

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Zachary Wu, Josh Abramson, Thomas Frerix, Alexander E. Chu, Ruijie K. Zhang, Luca Schulz, Amy E. Danson, Tristan O. C. Kwan, Li Kevin Wenliang, Jacob Kelly, Zi‐Qi Li, Rosalia G. Schneider, Ashok Thillaisundaram, Harshnira Hitesh Patani, Vinícius Zambaldi, , Jue Wang

This paper introduces AlphaProtein Novo, a machine-learning pipeline for de novo enzyme design that outperforms natural sequence mining in creating enzymes for new-to-nature chemistry and substrates.

bioRxiv · Oct 5, 2026 · PreprintSynthetic Biology

Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry

Zi‐Qi Li, Ruijie K. Zhang, Pei‐Pei Xie, Jacob Kelly, Yu Zhang, Ziyang Qin, Théophile Lambert, Orna Mukhopadhyay, Deirdre Hanley, Amy E. Danson, Josh Abramson, Sukhdeep Singh, Zachary Wu, Pushmeet Kohli, Peng Liu, , Frances H. Arnold

This study combines design and evolution to create new-to-nature enzymes capable of performing regio- and enantioselective C-H amination reactions for synthesizing chiral piperidines.

bioRxiv · Oct 2, 2026 · PreprintSynthetic Biology