Author

Pei‐Pei Xie

University of PittsburghORCID 0000-0002-7801-5232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Amy E. DansoniD· 1 shared Deirdre HanleyiD· 1 shared Frances H. ArnoldiD· 1 shared Jacob KellyiD· 1 shared Josh AbramsoniD· 1 shared Jue WangiD· 1 shared Orna MukhopadhyayiD· 1 shared Peng LiuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Amy E. DansonORCID

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1 paper

Recent·Most cited

Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry

Zi‐Qi Li, Ruijie K. Zhang, Pei‐Pei Xie, Jacob Kelly, Yu Zhang, Ziyang Qin, Théophile Lambert, Orna Mukhopadhyay, Deirdre Hanley, Amy E. Danson, Josh Abramson, Sukhdeep Singh, Zachary Wu, Pushmeet Kohli, Peng Liu, , Frances H. Arnold

This study combines design and evolution to create new-to-nature enzymes capable of performing regio- and enantioselective C-H amination reactions for synthesizing chiral piperidines.

bioRxiv · Oct 2, 2026 · PreprintSynthetic Biology