This pilot study identifies British South Asians at high risk of cholestatic liver disease through genetic and phenotypic recall, finding 66.7% of participants had undetected liver disease.

Communications Medicine · Dec 23, 2025Peer-reviewedGenetic & Genomic Medicine

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores

Timing Liu, Alagu Sankareswaran S., Gordon G. Paterson, Shaheen Akhtar, Ana Angel, Omar Asgar, Samina Ashraf, Saeed Bidi, Gerome D. Breen, James Broster, Raymond Chung, David Collier, Charles J. C. Curtis, Shabana Chaudhary, Grainne Colligan, , Giriraj R. Chandak

This study estimates that ~6% of insulin-treated diabetic individuals with ambiguous features in British Pakistanis and Bangladeshis have T1D, highlighting the need for autoantibody and C-peptide testing.

Scientific Reports · Jan 13, 2025Peer-reviewedGenetic & Genomic Medicine

PIK3R3 is a candidate regulator of platelet count in people of Bangladeshi ancestry

Kate Burley, Lucy Fitzgibbon, David A. van Heel, Shaheen Akhtar, Mohammad Anwar, Elena Arciero, Omar Asgar, Samina Ashraf, Gerome D. Breen, Raymond Chung, Charles J. C. Curtis, Shabana Chaudhary, Maharun Chowdhury, Grainne Colligan, Panos Deloukas, , Andrew David Mumford

The paper identifies PIK3R3 as a candidate regulator of platelet count in Bangladeshi ancestry individuals through GWAS and functional analysis.

Research and Practice in Thrombosis and Haemostasis · May 1, 2023Peer-reviewedGenomics