The paper identifies DNA methylation marks linked to body composition traits in children from India and The Gambia using an epigenome-wide association study.

DOAJ (DOAJ: Directory of Open Access Journals) · Jun 1, 2026Peer-reviewedGenomics

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

Alicia Huerta‐Chagoya, Joohyun Kim, Ravi Mandla, Yingchang Lu, Suzuki Ken, Lauren E. Petty, Hong Kiat Ng, Jaewon Choi, Simon Lee, Madhusmita Rout, Kuang Lin, Katherine Taylor, Carlos Alberto Aguilar-Salinas, Lourdes García‐García, Clicerio González‐Villalpando, , Xiuqing Guo

This paper develops and validates multi-ancestry polygenic risk scores for type 2 diabetes prediction and complications across diverse populations.

The Lancet Diabetes & Endocrinology · Apr 27, 2026Peer-reviewedGenetic & Genomic Medicine

Performance of a Type 1 Diabetes Genetic Risk Score in a Multi-centric Study from India and its Implications in Clinical Practice

Alagu Sankareswaran S., Dimple Lavanuru, Bhanu Teja Nalluri, Shalbha Tiwari, Rashmi Nagaraj, Nagendra Khadri, Akila Prashant, Srinivas G N S V Kandula, Vedavati Bharat Purandare, Vaibhavishree Muniswamy, Navyashree Mugur Jagadeesha, Prajwal Guruswamy, Kudugunti Neelaveni, Savitha MR, Radhe Shyam Tapadia, , Giriraj R. Chandak

This study evaluates the performance of a type 1 diabetes genetic risk score in Indian populations, finding it effective for classification but with variations based on autoantibody status and age at onset.

medRxiv · Feb 23, 2026 · PreprintGenetic & Genomic Medicine

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores

Timing Liu, Alagu Sankareswaran S., Gordon G. Paterson, Shaheen Akhtar, Ana Angel, Omar Asgar, Samina Ashraf, Saeed Bidi, Gerome D. Breen, James Broster, Raymond Chung, David Collier, Charles J. C. Curtis, Shabana Chaudhary, Grainne Colligan, , Giriraj R. Chandak

This study estimates that ~6% of insulin-treated diabetic individuals with ambiguous features in British Pakistanis and Bangladeshis have T1D, highlighting the need for autoantibody and C-peptide testing.

Scientific Reports · Jan 13, 2025Peer-reviewedGenetic & Genomic Medicine

Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative ability

Alagu Sankareswaran S., Pooja S. Kunte, Diane P. Fraser, Mobeen Shaik, Michael N. Weedon, Richard A. Oram, Chittaranjan Sakerlal Yajnik, Giriraj R. Chandak

The paper evaluates the performance of a type 1 diabetes genetic risk score in an Indian cohort, finding lower discriminative ability compared to Europeans due to HLA diversity.

medRxiv · Aug 31, 2024 · PreprintGenetic & Genomic Medicine

Zebrafish model of tcn2 deletion reveals new molecular insights into the role of vitamin B12 in embryonic development

Ajay Deepak Verma, Suraj Singh Nongmaithem, Challapalli Mounika, Swetha Ramachandran, Anushri Umesh, Giriraj R. Chandak

This study uses zebrafish tcn2 knockout to investigate B12's role in embryonic development, finding that B12 supplementation partially rescues developmental defects and alters gene expression in key pathways.

bioRxiv · Oct 14, 2023 · PreprintGenetics

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj Singh Nongmaithem, Alagu Sankareswaran S., Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail Rafik Mansuri, Maria Derakhshan, Ghattu V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, , Stephen Owens

This study identifies DNA methylation at the SOCS3 gene as a factor influencing child height in low and middle-income countries, with a causal effect confirmed by Mendelian randomization.

Nature Communications · Aug 25, 2023Peer-reviewedGenomics

Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

Maria Derakhshan, Noah J. Kessler, Miho Ishida, Charalambos Demetriou, Nicolas Brucato, Gudrun E. Moore, Caroline H. D. Fall, Giriraj R. Chandak, François‐Xavier Ricaut, Andrew M. Prentice, Garrett Hellenthal, Matt J. Silver

The paper identifies hypervariable DNA methylation sites across multiple tissues and ethnicities, showing they are influenced by environmental factors and established early in human development.

Nucleic Acids Research · Jun 17, 2022Peer-reviewedGenomics

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

Suraj Singh Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood, Babatunji-William Ogunkolade, Zahid Hassan, Ghattu V. Krishnaveni, Kalyanaraman Kumaran, Ramesh D. Potdar, Sirazul Ameen Sahariah, Murali Krishna, Chiara Di Gravio, Inder D Mali, Alagu Sankareswaran S., Akhtar Hussain, , Giriraj R. Chandak

This study examines genetic scores for birth weight in South Asians, finding associations with birth size, childhood body size, and adult cardiometabolic markers.

Diabetes · Jan 21, 2022Peer-reviewedGenetic & Genomic Medicine

Rapid, accurate, nucleobase detection using FnCas9

Mohd. Azhar, Rhythm Phutela, Manoj Kumar, Asgar Hussain Ansari, Riya Rauthan, Sneha Gulati, Namrata Sharma, Dipanjali Sinha, Saumya Sharma, Sunaina Singh, Sundaram Acharya, Sajal Sarkar, Deepanjan Paul, Poorti Kathpalia, Meghali Aich, , Souvik Maiti

FELUDA uses FnCas9 for rapid, accurate nucleobase detection and is implemented in a point-of-care diagnostic tool for SARS-CoV-2.

Biosensors and Bioelectronics · Apr 5, 2021Peer-reviewedGenetic & Genomic Medicine