James Skelton

The paper assesses an automated variant prioritisation strategy for genomic newborn screening in the Generation Study, finding that 3-5% of samples require manual review and <1% need confirmatory testing.

The paper demonstrates how the SBOL standard can represent multicellular biological systems, enabling better sharing of complex designs across multiple cells.

The paper develops an evolutionary algorithm to optimise coding sequences for multiple organisms, showing it can outperform single-organism optimisation in some cases.

The paper introduces Coevolution Similarity Networks (CSNs) to analyze enzyme families by clustering based on coevolution patterns, showing higher predictive power for substrate specificity annotation than Sequence Similarity Networks.