Author

Alexandra J. Noble

University of CanterburyORCID 0000-0001-7380-2248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Assay:DNA methylation· 4 Approach:statistical model· 4 Organism:human· 3 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amy J. OsborneiD· 4 shared John F. PearsoniD· 4 shared Joseph M. BodeniD· 4 shared L. John HorwoodiD· 4 shared Martin Alexander KennedyiD· 4 shared Neil J. GemmelliD· 2 shared Alasdair D. Noble· 1 shared Donia P Macartney-CoxsoniD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 33 mutual co-author links

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4 shared papersGenomics

Amy J. OsborneORCID

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4 papers

Recent·Most cited

Hypomethylation in FASTKD1 detected in the association between in utero tobacco exposure and conduct problem in a New Zealand longitudinal study

Alexandra J. Noble, John F. Pearson, Joseph M. Boden, L. John Horwood, Martin Alexander Kennedy, Amy J. Osborne

The paper investigates the association between in utero tobacco exposure and conduct problems in children, identifying hypomethylation at FASTKD1 as a potential mediator.

bioRxiv · Apr 8, 2021 · PreprintGenomics

A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing

Alexandra J. Noble, John F. Pearson, Joseph M. Boden, L. John Horwood, Neil J. Gemmell, Martin Alexander Kennedy, Amy J. Osborne

This study validates bisulfite-based amplicon sequencing (BSAS) as a method to validate CpG sites detected by the EPIC array, showing high correlation but lower specificity at larger methylation changes due to PCR amplification.

PeerJ · Feb 10, 2021Peer-reviewedGenomics

DNA methylation analysis of amplicons from individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence

Alexandra J. Noble, John F. Pearson, Alasdair D. Noble, Joseph M. Boden, L. John Horwood, Martin A. Kennedy, Amy J. Osborne

The paper examines if DNA methylation differences mediate the link between maternal tobacco use during pregnancy and offspring conduct problems, finding nominal significant methylation changes in specific genes.

bioRxiv · Jul 2, 2020 · PreprintGenomics

Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort

Amy J. Osborne, John F. Pearson, Alexandra J. Noble, Neil J. Gemmell, L. John Horwood, Joseph M. Boden, Miles C. Benton, Donia P Macartney-Coxson, Martin Alexander Kennedy

This study examines DNA methylation changes in cannabis users with and without tobacco use in a longitudinal cohort, finding distinct methylation patterns associated with cannabis exposure.

Translational Psychiatry · Apr 22, 2020Peer-reviewedGenomics