Martin Alexander Kennedy

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

Allelic diversity of the pharmacogene CYP2D6 in New Zealand Maori and Pacific peoples

The paper identifies novel CYP2D6 variants and suballeles in New Zealand Māori and Pacific populations, highlighting the high frequency of CYP2D6*71.

Exploring the clinical consequences and genetic aetiology of adult weight trajectories

This study examines the genetic and clinical associations of adult weight trajectories using EHR data, identifying disease links and genetic risk factors for weight patterns.

The Phenome-wide Consequences of Anorexia Nervosa Genes

This study uses transcriptomic imputation to translate AN GWAS findings into gene expression associations, revealing 47 genes linked to AN and their clinical consequences in a biobank cohort.

Hypomethylation in FASTKD1 detected in the association between in utero tobacco exposure and conduct problem in a New Zealand longitudinal study

The paper investigates the association between in utero tobacco exposure and conduct problems in children, identifying hypomethylation at FASTKD1 as a potential mediator.

Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms

A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing

This study validates bisulfite-based amplicon sequencing (BSAS) as a method to validate CpG sites detected by the EPIC array, showing high correlation but lower specificity at larger methylation changes due to PCR amplification.

DNA methylation analysis of amplicons from individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence

The paper examines if DNA methylation differences mediate the link between maternal tobacco use during pregnancy and offspring conduct problems, finding nominal significant methylation changes in specific genes.

Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort

This study examines DNA methylation changes in cannabis users with and without tobacco use in a longitudinal cohort, finding distinct methylation patterns associated with cannabis exposure.

Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinsons disease cohort

The paper uses nanopore sequencing to identify GBA variants in a Parkinson's disease cohort, finding several risk variants and a higher dementia prevalence among carriers.

A Multiplex Pharmacogenetics Assay using the MinION Nanopore Sequencing Device

The paper develops a multiplex pharmacogenetics assay using MinION nanopore sequencing to genotype variants related to clopidogrel and warfarin, achieving >90% accuracy for most variants.

Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications

This study uses nanopore sequencing to genotype CYP2D6, accurately haplotype alleles, and detect duplications by analyzing allelic balance.

Gene expression effects of lithium and valproic acid in a serotonergic cell line

This study uses RNA-Seq to compare gene expression changes in a rat serotonergic cell line exposed to lithium and valproic acid, identifying differentially expressed genes and pathways relevant to mood disorders.

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

The paper improves age prediction from DNA methylation using larger datasets, showing reduced error and limitations in capturing biological ageing variation.

The Anorexia Nervosa Genetics Initiative: Overview and Methods

The paper describes the methods and recruitment strategies of the Anorexia Nervosa Genetics Initiative (ANGI), which successfully enrolled 13,364 individuals with AN and controls for genetic research.

Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy

The paper identifies a high rate of rare copy number variants in women with earthquake-induced stress cardiomyopathy, suggesting potential genetic predisposition.

Multiplexed nanopore sequencing of HLA-B locus in Maori and Polynesian samples

The paper develops a method for HLA-B typing using nanopore sequencing and demonstrates its application in Maori and Polynesian populations.

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events

The paper uses nanopore sequencing to analyze full-length BRCA1 mRNA transcripts, identifying novel isoforms and co-occurring exon skipping events.