John F. Pearson

The paper identifies immune-related gene and microbial biomarkers associated with complete response to chemoradiotherapy in rectal cancer.

The paper identifies novel CYP2D6 variants and suballeles in New Zealand Māori and Pacific populations, highlighting the high frequency of CYP2D6*71.

The paper investigates the association between in utero tobacco exposure and conduct problems in children, identifying hypomethylation at FASTKD1 as a potential mediator.

This study validates bisulfite-based amplicon sequencing (BSAS) as a method to validate CpG sites detected by the EPIC array, showing high correlation but lower specificity at larger methylation changes due to PCR amplification.

The paper examines if DNA methylation differences mediate the link between maternal tobacco use during pregnancy and offspring conduct problems, finding nominal significant methylation changes in specific genes.

This study examines DNA methylation changes in cannabis users with and without tobacco use in a longitudinal cohort, finding distinct methylation patterns associated with cannabis exposure.

The paper develops a multiplex pharmacogenetics assay using MinION nanopore sequencing to genotype variants related to clopidogrel and warfarin, achieving >90% accuracy for most variants.

This study uses nanopore sequencing to genotype CYP2D6, accurately haplotype alleles, and detect duplications by analyzing allelic balance.

This study uses RNA-Seq to compare gene expression changes in a rat serotonergic cell line exposed to lithium and valproic acid, identifying differentially expressed genes and pathways relevant to mood disorders.

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

The paper describes the methods and recruitment strategies of the Anorexia Nervosa Genetics Initiative (ANGI), which successfully enrolled 13,364 individuals with AN and controls for genetic research.

The paper identifies a high rate of rare copy number variants in women with earthquake-induced stress cardiomyopathy, suggesting potential genetic predisposition.