Author

Dominic M. H. Tong

University of California, San FranciscoORCID 0000-0001-7396-7958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:GWAS summary statistics· 1 Approach:simulation· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ryan D. HernandeziD· 1 shared

Activity by Year

2019-2019 · peak 1/yr

1 paper

Recent·Most cited

GenomicsGenetic EpidemiologyPeer-reviewedOct 6, 2019

Population genetic simulation study of power in association testing across genetic architectures and study designs

Dominic M. H. Tong, Ryan D. Hernandez

This study simulates rare variant association tests across different genetic architectures and study designs to evaluate their statistical power and find that extreme trait sampling and imputation improve power, but RVATs still lack power for dichotomous traits.

9 citations

GWAS summary statisticsstatistical model

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