Ryan D. Hernandez

The paper reconstructs the demographic history of Rice's whale using whole-genome sequences and assesses its genomic health, finding long-term isolation and a recent population collapse increase extinction risk.

py_ped_sim simulates pedigree structures and genomes for family analysis, accurately approximating kinship coefficients in diverse pedigrees.

PROPEL is a postbaccalaureate program that trains scholars from underrepresented backgrounds in biomedical research, demonstrating its scalability and impact.

The paper estimates genetic and environmental correlations between complex phenotypes across different racial/ethnic groups and sexes using data from the TOPMed program.

The paper shows that increased Amerindigenous ancestry in Mexican Americans over time has altered the genetic architecture of traits like height and polygenic risk scores.

The paper analyzes de novo mutations in 1,465 genomes to show similar mutation rates across ancestries but reduced rates in the Amish population, with environmental factors possibly influencing mutation rates.

The paper decomposes mutation rate and spectra variation in human germline using blind source separation, identifying nine processes including those related to DNA damage and replication timing.

The paper compares two heritability estimation methods and finds low frequency variants contribute significantly to heritability of complex traits.

This study simulates rare variant association tests across different genetic architectures and study designs to evaluate their statistical power and find that extreme trait sampling and imputation improve power, but RVATs still lack power for dichotomous traits.

The paper analyzes ROH in admixed populations and finds that deleterious homozygotes are more common in ROH overlapping African ancestry segments.

This study identifies genetic variants associated with bronchodilator drug response in African Americans with asthma, finding both population-specific and shared genetic factors across African American and Latino populations.

This study shows Ebola virus can infect boa constrictor cells without causing cytopathic effect or requiring genomic adaptation, while Marburg virus cannot.

This study identifies pharmacogenetic variants associated with albuterol bronchodilator response in minority children with asthma using whole genome sequencing.

This paper introduces ROP to identify the source of unmapped RNA-Seq reads across diverse tissues, showing it can account for 99.9% of 1 trillion reads and reveals immune and microbial correlations.

The paper analyzes amino acid mutation patterns across 29 cancers, identifying six mutation signatures, five of which are validated using COSMIC data.

The paper designs a genotyping array (ADPC) for African-specific genetic variation using whole genome sequences from the CAAPA consortium, improving GWAS for African ancestry populations.

This study identifies novel asthma susceptibility loci in individuals of African ancestry through genome-wide association analysis and admixture mapping.

The paper shows rare variant association tests have lower power than expected, suggesting poor performance rather than minimal contribution of rare variants to heritability.

The paper introduces an updated version of SFS_CODE with improved efficiency and new features for forward population genetic simulations, along with a Python wrapper for easier model generation and analysis.