Ronaldo da Silva Francisco

The paper develops a multi-optosis model integrating 25 RCD forms across 33 cancer types to discover candidate biomarkers and therapy targets using multi-omic and phenotypic data.

This study identifies P2RX7 as a key regulator of Treg suppressive function in lung tumors, showing that targeting P2RX7 could improve lung cancer treatment by reducing Treg-mediated immune suppression.

The paper analyzes Brazilian respiratory syndrome data and community mobility changes to assess data quality, estimate cases from mobility patterns, detect disease waves, and cluster cities by behavior.

The paper identifies key mutations in SARS-CoV-2 variants of concern that affect structural stability and presents methods to associate these mutations with conformational changes and functional impacts.

The paper identifies differential haplotype expression in MHC class I genes during SARS-CoV-2 infection in human lung cell lines, showing allele-specific switching linked to epitope binding affinity.

The paper reports the genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil, identifying five SNVs and the E484K mutation associated with antibody escape.

The paper investigates the spread of the E484K variant and identifies a novel lineage VUI-NP13L in Brazil, along with co-infection events between different SARS-CoV-2 lineages.