Author

Igor Santiago-Carvalho

Mayo ClinicORCID 0000-0002-8482-436XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 1

Frequent Co-Authors

Bruna de Gois MacedoiD· 3 shared Maria Regina D’Império LimaiD· 3 shared Caio Loureiro SalgadoiD· 2 shared Henrique Borges da SilvaiD· 2 shared Bárbara Cristina Pizzolante· 1 shared Bernardo de Castro OliveiraiD· 1 shared Caio César Barbosa BomfimiD· 1 shared Camila Ramos SilvaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

Bruna de Gois MacedoORCID

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3 papers

Recent·Most cited

CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS

Gislane de Almeida Santos, Igor Santiago-Carvalho, Fabrício Moreira Almeida, Caio César Barbosa Bomfim, Juan Carlo Santos e Silva, Déborah Giovanna Cantarini, Camila Ramos Silva, Martha Simões Ribeiro, Rogério Silva do Nascimento, Bruna de Gois Macedo, Paulo Lisboa Raeder, Joaquim Teixeira-Xavier, José María Álvarez, Mário Hiroyuki Hirata, Robson Coutinho‐Silva, , Maria Regina D’Império Lima

This study shows CD39 prevents necrotic lung lesions in tuberculosis by inhibiting P2RX7-mediated macrophage death and inflammation.

Mucosal Immunology · Mar 14, 2026Peer-reviewedImmunology

Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses

Caio Loureiro Salgado, Marina Caçador Ayupe, Juliana Falcão Rodrigues, Leonardo Mandu Gonçalves, Luísa Menezes-Silva, Bárbara Cristina Pizzolante, Bernardo de Castro Oliveira, Guilherme William da Silva, Francielly Moreira, Érick Esteves de Oliveira, Marcelo Valdemir de Araújo, Gabriele Manamy Baba Rodrigues, Jofer Andree Zamame Ramirez, Kristen Brammer, Igor Santiago-Carvalho, , Denise Morais da Fonseca

This study shows that exposure to ETEC or its toxin LT reduces lung allergic inflammation by inhibiting IL-33 responses in ILC2 cells through a gut-derived negative feedback loop.

bioRxiv · Nov 7, 2025 · PreprintImmunology

Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function

Igor Santiago-Carvalho, Ronaldo da Silva Francisco, Bruna de Gois Macedo, Caio Loureiro Salgado, Carly R. Stoll, Marcos Pinheiro Cione, Emily White, Tyler Johnston, Chloe Liliana Leff, Ildefonso Silva, Fabio Carvalho de Souza, Maria Regina D’Império Lima, Jessica Naomi Lancaster, Henrique Borges da Silva

This study identifies P2RX7 as a key regulator of Treg suppressive function in lung tumors, showing that targeting P2RX7 could improve lung cancer treatment by reducing Treg-mediated immune suppression.

bioRxiv · May 3, 2025 · PreprintImmunology