Alexander Gow

Why rescue-based transcript ranking can mislead: normalization displacement and shared-control coupling in perturbation transcriptomics

The paper shows how rescue-based transcript ranking can mislead in perturbation transcriptomics due to normalization issues and shared-control coupling.

MyeliMetric: A Python-Based Toolbox for Standardized G-ratio Analysis of Axon-Myelin Integrity

MyeliMetric provides a standardized tool for analyzing g-ratios from electron microscopy images, improving accuracy and reducing artifacts in myelin integrity assessments.

Demystifying The Myelin g ratio: Its Origin, Derivation and Interpretation

The paper challenges assumptions about the myelin g ratio, showing it can inaccurately represent myelin structure in non-steady states and proposes alternative metrics.

A Statistically-Robust Model Of The Axomyelin Unit Under Normal Physiologic Conditions With Application To Disease States

The paper develops a statistically-robust analysis pipeline to examine axomyelin physiology and pathobiology in two disease states, highlighting limitations of common statistical methods.

Understanding The Myelin g ratio From First Principles, Its Derivation, Uses And Artifacts

The paper analyzes the myelin g ratio from first principles, identifies artifacts in current methodologies, and proposes a framework for accurate interpretation.