Jeffrey L. Dupree

This study shows that ORMDL3 regulates sphingolipid and protein synthesis in oligodendrocytes, affecting myelin structure and composition during development.

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

The paper develops a statistically-robust analysis pipeline to examine axomyelin physiology and pathobiology in two disease states, highlighting limitations of common statistical methods.

This study investigates the relationship between sulfatide deficiency, neuroinflammation, and lipid dyshomeostasis in a mouse model, showing Trem2's role in microglia-mediated neuroinflammation but not astrogliosis or myelin lipid disruption.

This study shows that CNS sulfatide deficiency causes sex-dependent metabolic changes in aging, with females showing more severe metabolic disruption than males.

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

The paper investigates axon initial segment alterations in multiple sclerosis, finding increased soma-axon initial segment gap in both active and inactive lesions.

This study identifies YY1's role in regulating cerebellar astrocyte maturation and maintenance in adult mice through single-cell RNA-seq analysis.