Author

Jun Lyu

National Institutes of HealthORCID 0000-0001-7493-8024Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdelmonsif Ahmed· 1 shared Chongyi CheniD· 1 shared Ipsita Biswas· 1 shared Shuai LiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperGenomics

Abdelmonsif Ahmed

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1 paper

Recent·Most cited

Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation

Jun Lyu, Abdelmonsif Ahmed, Ipsita Biswas, Shuai Li, Chongyi Chen

This study shows that topoisomerase-mediated resolution of negative DNA supercoiling is essential for productive transcription and gene activation in human cells.

bioRxiv · Oct 2, 2026 · PreprintGenomics