Shuai Li

Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation

This study shows that topoisomerase-mediated resolution of negative DNA supercoiling is essential for productive transcription and gene activation in human cells.

Genome-wide mapping of endogenous topoisomerase cleavage complexes reveals TOP1 at the interface of DNA topological regulation and genome instability

This study introduces pDAIP-seq, a method to map endogenous topoisomerase cleavage complexes, revealing their genomic distribution and role in DNA breaks and genome instability.