Author

Daniela Winkler

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)ORCID 0000-0001-7501-2506Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

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Approach:experimental assay· 1

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Chloe LangleyiD· 1 shared Hajo KriesiD· 1 shared J. BasquiniD· 1 shared Lorenzo CaputiiD· 1 shared Philipp Stephan· 1 shared Sarah Ellen O'ConnoriD· 1 shared

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2023-2023 · peak 1/yr

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Chloe LangleyORCID

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Synthetic BiologyAngewandte Chemie International EditionPeer-reviewedJun 16, 2023

Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase

Philipp Stephan, Chloe Langley, Daniela Winkler…·Hajo Kries

The paper reports directed evolution of an NRPS adenylation domain to incorporate piperazic acid, demonstrating that low-throughput methods can alter NRPS substrate specificity.

24 citations

experimental assay

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