Author

Yosuke Demizu

National Institute of Health SciencesORCID 0000-0001-7521-4861Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Approach:machine learning (classical)· 1 Approach:optimal transport· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Akira R. KinjoiD· 1 shared Hidetomo YokooiD· 1 shared Iori YamahataiD· 1 shared Koji TsudaiD· 1 shared Ryo TamuraiD· 1 shared Shuichi KawashimaiD· 1 shared Shuto HayashiiD· 1 shared Teppei ShimamuraiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBioinformatics

Akira R. KinjoORCID

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2 papers

Recent·Most cited

BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedSep 10, 2026

Closed-Loop Multi-Objective Optimization for Receptor-Selective Cell-Penetrating Peptide Design

Iori Yamahata, Hidetomo Yokoo, Yosuke Demizu…·Shuto Hayashi

The paper develops a closed-loop framework for designing receptor-selective cell-penetrating peptides using multi-objective optimization and evaluates its effectiveness through experimental validation.

DOI 10.1021/acs.jcim.6c01267

protein sequencemachine learning (classical)

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 7, 2026

BacteReason: A Reasoning Model for Antimicrobial Resistance Prediction

Yuna Oikawa, Shuichi Kawashima, Akira R. Kinjo…·Koji Tsuda

BacteReason predicts bacterial antibiotic susceptibility with mechanistic rationales, improving accuracy over baselines using reasoning supervision.

DOI 10.64898/2026.06.04.730229

large language modeldrug response / drug discovery

𝕏 PostBluesky