Molecular BiologyNature CommunicationsPeer-reviewed
Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami…·Anissa Anindya Widjaja
The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.
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