Author
National University of SingaporeORCID 0000-0001-8858-0078Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Benjamin Ng, Anissa Anindya Widjaja, Sivakumar Viswanathan…·Stuart A. Cook
This study compares IL11 and IL11RA1 knockout mice, finding IL11 deficiency protects against lung fibro-inflammation but causes infertility, while IL11RA1 deficiency leads to craniosynostosis.
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami…·Anissa Anindya Widjaja
The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.
Benjamin Ng, Jinrui Dong, Giuseppe Alessandro D’Agostino…·Stuart A. Cook
The paper identifies IL-11 as a therapeutic target in idiopathic pulmonary fibrosis by showing its role in fibroblast activation and fibrosis progression across species.
Sonia Pankaj Chothani, Sebastian Schäfer, Eleonora Adami…·Owen J. L. Rackham
The paper identifies translational regulators of fibrogenic genes in human cardiac fibroblasts and shows their role in cardiac fibrosis through ribosome profiling and RNA-binding protein analysis.
Anissa Anindya Widjaja, Brijesh Kumar Singh, Eleonora Adami…·Stuart A. Cook
This study identifies IL-11 as a key driver of HSC-to-myofibroblast transformation in NASH, showing that targeting IL-11 reduces fibrosis and inflammation in preclinical models.