Retrosplenial cortex vulnerability links severe hypoglycemia to cognitive impairment through neuron-microglia crosstalk
Jae-Young Joo, Soyun Lee, Min Kyoung Shin, Sunmin Kim, S Y Park, Jun H. Heo, Minjung Kim, Hyojung Lee, Kyunghyuk Park, Dongjun Koo, Ho‐Young Lee, Jong-Il Kim, Obin Kwon
This study identifies the retrosplenial cortex as a brain region vulnerable to hypoglycemia-induced neuronal damage through neuron-microglia crosstalk, and shows targeting this pathway can reverse cognitive impairment.
bioRxiv · Mar 27, 2026 · PreprintNeuroscience