Jong‐Il Kim

Agentic AI enables cell segmentation-free cell-type inference and cell-type-guided cell segmentation in spatial transcriptomics

This paper introduces SSAF-T, a segmentation-free framework for cell-type inference in spatial transcriptomics that avoids cell segmentation and enables accurate cell-type-guided segmentation.

Retrosplenial cortex vulnerability links severe hypoglycemia to cognitive impairment through neuron-microglia crosstalk

This study identifies the retrosplenial cortex as a brain region vulnerable to hypoglycemia-induced neuronal damage through neuron-microglia crosstalk, and shows targeting this pathway can reverse cognitive impairment.

Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9

This study identifies ZDHHC9 as a key regulator of oligodendrocyte morphology and myelination, showing its role in palmitoylation of MBP and its impact on XLID.

Expression Based Species Deconvolution and Realignment Removes Misalignent Error in Multi-species Single Cell Data

The paper develops a bioinformatics pipeline to reduce misalignment errors in mixed human and mouse single-cell RNA sequencing data, improving clustering and accuracy compared to existing methods.

Ablation of STAT3 in Purkinje Cells Reorganizes Cerebellar Synaptic Plasticity in Long-Term Fear Memory Network

This study shows that deleting STAT3 in Purkinje cells alters synaptic plasticity and enhances long-term fear memory.

Whole-genome reference panel of 1,781 Northeast Asians improves imputation accuracy of rare and low-frequency variants

The paper introduces a whole-genome reference panel of 1,781 Northeast Asians, showing improved imputation accuracy for rare and low-frequency variants compared to existing panels.

Human Reference Genome and a High Contiguity Ethnic Genome AK1

The paper compares the human reference genome GRCh38 with a high contiguity ethnic genome AK1 to identify missing sequences and their implications for human genetics.