Author

Aspasia Orfanou

Centre for Research and Technology HellasORCID 0000-0001-7590-6235Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:simulation· 2 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Fotis E PsomopoulosiD· 2 shared Nikolaos PechlivanisiD· 2 shared Abayomi S. OlabodeiD· 1 shared Alexandre DefelicibusiD· 1 shared Alyssa K. OvertoniD· 1 shared Anastasia Anastasiadou· 1 shared Andreas AgathangelidisiD· 1 shared Art F. Y. PooniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Fotis E PsomopoulosORCID

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2 papers

Recent·Most cited

BioinformaticsFrontiers in BioinformaticsPeer-reviewedJul 16, 2026

Synth4bench: Synthetic Data Generation for Benchmarking Tumor-Only Somatic Variant Calling Algorithms

Styliani-Christina Fragkouli, Nikos Pechlivanis, Anastasia Anastasiadou…·F. Psomopoulos

The paper develops synth4bench, a synthetic data pipeline to benchmark tumor-only somatic variant callers, revealing inconsistencies in tool performance and highlighting the need for sequencing optimization and caller selection.

DOI 10.3389/fbinf.2026.1858375

whole-exome sequencingsimulation

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BioinformaticsMicrobial GenomicsPeer-reviewedMay 24, 2024

Tracking SARS-CoV-2 variants of concern in wastewater: an assessment of nine computational tools using simulated genomic data

Steven G. Sutcliffe, Susanne A. Kraemer, Isaac Ellmen…·B. Jesse Shapiro

The paper evaluates nine computational tools for identifying SARS-CoV-2 lineages in wastewater sequencing data using simulated samples, finding most tools reliably detect lineages above 5% frequency.

19 citationstop 2%

whole-genome sequencingsimulation

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