Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma
Santoesha A. Ghisai, Levi van Hijfte, W. R. Vallentgoed, C. Mircea S. Tesileanu, Iris J. de Heer, Johan M. Kros, Marc Sanson, Thierry Gorlia, Wolfgang Wick, Michael A. Vogelbaum, Alba Ariela Brandes, Enrico Franceschi, Paul M. Clément, Anna K. Nowak, Vassilis Golfinopoulos, , Youri Hoogstrate
This study identifies DNA-methylation and RNA-expression signatures that improve grading of IDH-mutant astrocytomas beyond current methods.
Acta Neuropathologica · Oct 9, 2024Peer-reviewedCancer Biology