Author

Santoesha A. Ghisai

Erasmus MCORCID 0000-0002-3289-4294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Iris J. de HeeriD· 2 shared Levi van HijfteiD· 2 shared Martin J. van den BentiD· 2 shared Pim J. FrenchiD· 2 shared W. R. VallentgoediD· 2 shared Youri HoogstrateiD· 2 shared Adé la BrzobohatáiD· 1 shared Adelheid Wöhrer· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

Iris J. de HeerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

Youri Hoogstrate, Santoesha A. Ghisai, Levi van Hijfte, Rania Head, Iris J. de Heer, Marta Padovan, Maurice de Wit, Wies Vallentgoed, Angelo Dipasquale, Maarten M.J. Wijnenga, Bas Weenink, Rosa Luning, Sybren L. N. Maas, Adé la Brzobohatá, Michael Weller, , Pim J. French

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

Cell Reports Medicine · Mar 1, 2026Peer-reviewedCancer Biology

Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma

Santoesha A. Ghisai, Levi van Hijfte, W. R. Vallentgoed, C. Mircea S. Tesileanu, Iris J. de Heer, Johan M. Kros, Marc Sanson, Thierry Gorlia, Wolfgang Wick, Michael A. Vogelbaum, Alba Ariela Brandes, Enrico Franceschi, Paul M. Clément, Anna K. Nowak, Vassilis Golfinopoulos, , Youri Hoogstrate

This study identifies DNA-methylation and RNA-expression signatures that improve grading of IDH-mutant astrocytomas beyond current methods.

Acta Neuropathologica · Oct 9, 2024Peer-reviewedCancer Biology