Wolfgang Wick

The paper shows brain metastases form gap-junction-coupled networks with coordinated calcium activity that drives proliferation and is inhibited by gap junction blockers.

This study identifies shared early impairments in spatial context representation in the medial entorhinal cortex across two distinct Alzheimer's disease mouse models.

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

The paper introduces molecular recorders to track kinase activity in cells and applies them to study PKA activity and neuromodulation.

This study uses single-cell multiomics to identify regulatory programs and plasticity regulators in glioblastoma, revealing MYT1L as a key repressor of malignant plasticity.

This paper introduces OncoMimics, a peptide-based immunotherapy using molecular mimicry between commensal bacterial and tumor antigens to induce cross-reactive T cell responses, showing early clinical success in glioblastoma.

This study identifies DNA-methylation and RNA-expression signatures that improve grading of IDH-mutant astrocytomas beyond current methods.

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

This paper introduces moleculaR, a computational framework for probabilistic mapping and statistical testing of metabolites in mass spectrometry imaging data.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

The paper identifies ROS1 fusions in various glioma types through genomic and transcriptomic analysis, showing they are not restricted to specific subtypes.