Jacqueline Dresch

This paper introduces dLEM, a differentiable loop extrusion model that predicts genome folding mechanisms from contact maps and integrates with deep learning to infer extrusion parameters from genomic features.

The paper presents a whole genome DNA methylation profile of Dictyostelium discoideum, revealing a sparse but robust pattern of 5-methyl-cytosine associated with genes and retrotransposable elements.