Hemin-induced platelet activation is regulated via ACKR3 chemokine surface receptor - implications for passivation of vulnerable atherosclerotic plaque
Zoi Laspa, Valerie Dicenta, David Schaale, Manuel Sigle, Ravi Hochuli, Tatsiana Castor, Alp Bayrak, Tobias Harm, Karin Müller, Thanigaimalai Pillaiyar, Stefan Laufer, Anne‐Katrin Rohlfing, Meinrad Paul Gawaz
This study shows hemin activates platelets and promotes thrombosis, which can be inhibited by ACKR3 agonists, suggesting a potential therapeutic strategy for atherosclerotic plaque vulnerability.
FEBS Journal · Oct 10, 2024Peer-reviewedCell Biology