RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids
Adva Hadar, Kalina Draganova, Vinithra Iyer, B Bhattacharya, Yehonadav Komemy, Isaac Ponce, Leilah Krounbi, Itay Vaknin, Nili Dezorella, Lee Wilk, Anna Lilja, Svetlana Doroshev, Tsviya Olender, Miri Danan-Gotthold, Jianping Fu, , Orly Reiner
This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.
bioRxiv · Aug 21, 2026 · PreprintNeuroscience