Jianping Fu

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.

The paper develops a comprehensive reference tool for human embryogenesis using integrated single-cell RNA-sequencing data to benchmark embryo models.

This paper describes a transgene-free human embryo model that recapitulates peri-gastrulation development, including trilaminar embryonic disc and yolk sac-like structures.

The paper investigates how substrate rigidity affects oscillatory behavior in zebrafish presomitic mesoderm cells, finding a switch-like transition at a critical rigidity threshold.

The paper creates a cell atlas of early human peri-implantation lineages and develops an embryo-like assembloid to study lineage development and signaling mechanisms.

The paper identifies LTR5_Hs viral proteins and virus-like particles in hPGCLCs, showing their activation during early germ cell development and suppression upon gonadal anlagen settlement.

The paper identifies ISL1's critical role in primate mesoderm formation through a transcriptional atlas and CRISPR experiments in non-human primates.

The paper shows engineered substrates promoting cell-cell adhesion drive gastrulation-like self-organization in hESCs by enhancing cell tension and Wnt signaling to specify mesoderm.