Tsviya Olender

The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

The paper decodes BMP/TGFβ signaling from single-cell transcriptomes by identifying a low-dimensional transcriptional code and training a model to infer ligand concentrations.

The paper identifies iridosomes as a subtype of lysosome-related organelles (LROs) in zebrafish, showing their role in guanine crystal formation through molecular and structural analysis.

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

This study investigates the molecular pathways in leucophores, revealing shared and distinct mechanisms with other pigment cells for crystal formation.

This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.

The paper identifies an amphipathic helix as a targeting motif for ER surface proteins in yeast and humans, showing its conservation and role in membrane localization.

The paper investigates PRDM16's role in human brain development by analyzing a patient mutation and cortical organoids, revealing its collaboration with LHX2 in gene regulation.

This study shows that constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial identity in mice and human stem cell-derived organoids.

The paper identifies non-coding variants in the IL18RAP 3'UTR that reduce ALS risk by modulating neuro-inflammation through NF-κB signaling in microglia.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

The paper identifies SECReTE cis-acting RNA motifs in SARS-CoV-2 and other (+)ssRNA viruses, showing their association with ER-related functions and potential as drug targets.