Author

Matthew E. Spector

University of PittsburghORCID 0000-0001-7646-6075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adrian V. LeeiD· 1 shared Alan P. BoyleiD· 1 shared Andrew G. ShumaniD· 1 shared Apurva Dhanesh Bhangale· 1 shared Brian Robert IsettiD· 1 shared Carl Kim· 1 shared Carly ReederiD· 1 shared Chaz L. StuckeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Adrian V. LeeORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 10, 2026

Spatiotemporal Heterogeneity of HPV Integration Architectures Drive Oncogenic Features of Oropharyngeal Cancer

Wenjin Gu, Apurva Dhanesh Bhangale, Xiaomeng Du…·John Chad Brenner

The paper characterizes HPV integration structures in oropharyngeal cancer and links Type2 integration to oncogenic features and aggressive tumor behavior.

DOI 10.64898/2026.10.03.756294

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintJun 24, 2025

Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer

Rose Doerfler, Jie Chen, Carl Kim…·Riyue Bao

This study establishes patient-derived organoids (PDOs) for HNSCC drug response testing, integrating AI-driven histopathology and multi-omics analysis to create a scalable preclinical model.

3 citations

humanbulk RNA-seq

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