Brian Robert Isett

This study identifies tumor-intrinsic p38 activation as a driver of immune exclusion in epithelial cancers and suggests it as a therapeutic target to overcome immunotherapy resistance.

CosMxScope integrates spatial transcriptomics data with digital pathology tools by stitching images, converting spatial data to GeoJSON, and enabling visualization of gene expression and cell types.

This study establishes patient-derived organoids (PDOs) for HNSCC drug response testing, integrating AI-driven histopathology and multi-omics analysis to create a scalable preclinical model.

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

This study shows that optogenetic stimulation of A2A-SPNs in the striatum drives negative reinforcement via the indirect pathway, not motor suppression.