The tubulin poly-glutamylase complex, TPGC, is required for phosphatidyl inositol homeostasis and cilium assembly and maintenance
Binshad Badarudeen, Hung-Ju Chiang, Loren Collado, Lei Wang, Irma Sánchez, Brian David Dynlacht
This study identifies TBC1D19 and KIAA1841 as essential subunits of the TPGC complex, showing their role in ciliary poly-glutamylation and phosphatidyl inositol homeostasis.
bioRxiv · Mar 3, 2025 · PreprintCell Biology