Fine-tuning of coumaric acid synthesis to increase naringenin production in yeast
Jiwei Mao, Marta Tous Mohedano, Xiaowei Li, Quanli Liu, Jens Nielsen, Verena Siewers, Yun Chen
This study improves (2S)-naringenin production in yeast by fine-tuning p-coumaric acid synthesis, reducing its extracellular accumulation and increasing yield to 933 mg/L.
bioRxiv · Jun 20, 2022 · PreprintSynthetic Biology