Cameron P. Bracken

The paper investigates whether reported miRNAs in cancer are functionally active, finding many are not incorporated into RISC and lack endogenous silencing capability.

The paper shows that over half of annotated human miRNAs are not expressed at biologically significant levels, challenging the validity of many miRNA function studies.

The paper maps alternative polyadenylation changes during EMT in human mammary epithelial cells and identifies QKI's role in regulating APA and gene expression.

pDriver identifies personalized coding and miRNA cancer drivers for individual patients using gene networks and outperforms existing methods on TCGA datasets.

DriverGroup identifies driver gene groups in cancer by analyzing gene expression and interaction data, showing improved performance over existing methods in detecting gene group regulation and providing insights into breast cancer.

The paper shows that multiple microRNAs work together to control EMT by reducing noise and enhancing gene expression changes, more accurately reflecting endogenous regulation.