FOXP-stabilization of the Il2ra super-enhancer structure augments Treg fitness
Dachuan Dong, Lauren E. Higdon, Jiayan Zhou, Jian-Xin Lin, Jyothi Padiadpu, Yesl Kim, Warren J. Leonard, Jonathan S. Maltzman
The paper shows FOXP1 and FOXP4 maintain the peripheral Treg pool by regulating chromatin structure at the Il2ra locus to sustain CD25 expression.
bioRxiv · Apr 17, 2026 · PreprintImmunology