Author
National Institutes of HealthORCID 0000-0002-5740-7448Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Dachuan Dong, Lauren E. Higdon, Jiayan Zhou, Jian-Xin Lin, Jyothi Padiadpu, Yesl Kim, Warren J. Leonard, Jonathan S. Maltzman
The paper shows FOXP1 and FOXP4 maintain the peripheral Treg pool by regulating chromatin structure at the Il2ra locus to sustain CD25 expression.
bioRxiv · Apr 17, 2026 · PreprintImmunology
Anand Kumar Gupta, Jing Wu, Pijush K. Das, Rahul Sharma, Sonali Das, Kim Han, Rachael J. Klein, Rebecca D. Huffstutler, Christian A. Combs, Warren J. Leonard, Claudia Kemper, Erin E. West, Michael N. Sack
This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.
bioRxiv · Jan 21, 2026 · PreprintImmunology
Jung-Ho Chun, Birkley S. Lim, Suyasha Roy, Michael J. Walsh, Gita C. Abhiraman, Kevin Zhangxu, Tavus Atajanova, Or‐Yam Revach, Elisa C. Clark, Peng Li, Claire A. Palin, Asheema Khanna, Samantha J Tower, Rakeeb Kureshi, Megan T. Hoffman, , David A. Baker
This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.
Science Immunology · Sep 26, 2025Peer-reviewedBiochemistry
Peng Li, Sree H. Pulugulla, Sonali Das, Jangsuk Oh, Rosanne J. Spolski, Jian‐Xin Lin, Warren J. Leonard
The paper introduces SPICE, a pipeline for identifying composite DNA elements, and discovers novel JUN-IKZF1 interactions in the IL10 gene.
eLife · Dec 30, 2024Peer-reviewedSystems Biology