uORF-targeting steric block antisense oligonucleotides do not reproducibly activate RNASEH1 expression
Nina Ahlskog, Nenad Svrzikapa, Rushdie Abuhamdah, Mahnseok Kye, Yahya E. Jad, Ning Feng, Britt Hanson, Matthew J. A. Wood, Thomas C. Roberts
The paper tests uORF-targeting ASOs for RNASEH1 upregulation but finds no reproducible activation, instead observing downregulation in some cases.
Molecular Therapy — Nucleic Acids · Nov 28, 2024Peer-reviewedBiochemistry