Author

Britt Hanson

University of OxfordORCID 0000-0002-8518-4165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Matthew J. A. WoodiD· 4 shared Nenad SvrzikapaiD· 4 shared Thomas C. RobertsiD· 4 shared Hans J. Friedrichsen· 2 shared Katarzyna Chwalenia· 2 shared Nina AhlskogiD· 2 shared Ning FengiD· 2 shared Rushdie Abuhamdah· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMolecular Biology

Matthew J. A. WoodORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeted BDNF upregulation via upstream open reading frame disruption

Feng Ning, Thomas Goedert, Nenad Svrzikapa, Dongnan Yan, Hans J. Friedrichsen, Britt Hanson, Alicia Ljungdahl, Ruxandra Dafinca, Kevin Talbot, Stephan Sanders, Dhanu Gupta, Matthew J. A. Wood, Thomas C. Roberts

This study identifies uORF elements regulating BDNF translation and demonstrates that disrupting uORFs can upregulate BDNF expression in cell culture.

Molecular Therapy · Dec 11, 2025Peer-reviewedMolecular Biology

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach

Britt Hanson, Nenad Svrzikapa, Ning Feng, Hans J. Friedrichsen, Angus J. Lennaárd, Rushdie Abuhamdah, Nicole Hemmer, Katarzyna Chwalenia, Matthew Drake, Yahya E. Jad, Samir EL Andaloussi, Matthew J. A. Wood, Thomas C. Roberts

The paper combines experimental and computational methods to model how uORFs regulate translation, identifying key features and interactions that influence their repressive activity.

bioRxiv · Jul 28, 2025 · PreprintBiochemistry

uORF-targeting steric block antisense oligonucleotides do not reproducibly activate RNASEH1 expression

Nina Ahlskog, Nenad Svrzikapa, Rushdie Abuhamdah, Mahnseok Kye, Yahya E. Jad, Ning Feng, Britt Hanson, Matthew J. A. Wood, Thomas C. Roberts

The paper tests uORF-targeting ASOs for RNASEH1 upregulation but finds no reproducible activation, instead observing downregulation in some cases.

Molecular Therapy — Nucleic Acids · Nov 28, 2024Peer-reviewedBiochemistry

Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD

Britt Hanson, Sofia Stenler, Nina Ahlskog, Katarzyna Chwalenia, Nenad Svrzikapa, Anna M. L. Coenen-Stass, Marc S. Weinberg, Matthew J. A. Wood, Thomas C. Roberts

This study uses CRISPR to excise exon 23 in dKO mice, achieving partial dystrophin restoration but with limited efficacy and challenges in DNA repair.

Molecular Therapy — Nucleic Acids · Oct 23, 2022Peer-reviewedMolecular Biology